nav emailalert searchbtn searchbox tablepage yinyongbenwen piczone journalimg journalInfo searchdiv qikanlogo popupnotification paper paperNew
2016, 05, v.29 381-384
异荭草素的药理作用
基金项目(Foundation): 中央高校基本科研业务费专项资金资助项目(08143008,08143101)
邮箱(Email):
DOI: 10.16289/j.cnki.1002-0837.2016.05.014
摘要:

异荭草素是一种木犀草素糖苷类黄酮化合物,存在于多种药用植物中。异荭草素具有多种药理活性,如抗氧化、抑制炎症发展、改善胰岛素抵抗、弱化肝纤维化发展以及诱导肝癌细胞凋亡等。本文综述了近几年来异荭草素药理作用及相应机制研究的进展,并对如何推进异荭草素在肝癌治疗领域的应用提出了建议和展望。

Abstract:

As a C-glycosylation flavonoid of luteolin,isoorientin is one of the bioactive ingredients from many medical plants. Isoorientin possesses multiple pharmacological activities,including anti-oxidative,inflammation inhibition,insulin resistance improvement,liver fibrosis attenuation,and hepatic carcinoma apoptosis,et al. The present review summarized the advances in pharmacological effects and molecular mechanisms of isoorientin in recent years. How to promote the applications of isoorientin in liver cancer treatment was also discussed.

参考文献

[1]Soulimani R,Younos C,Jarmouni S,et al.Behavioural effects of Passiflora incarnata L.and its indole alkaloid and flavonoid derivatives and maltol in the mouse[J].Journal of Ethnopharmacology,1997,57(1):11-20.

[2]Sezik E,Aslan M,Yesilada E,et al.Hypoglycaemic activity of Gentiana olivieri and isolation of the active constituent through bioassay-directed fractionation techniques[J].Life Sciences,2005,76(11):1223-1238.

[3]Revilla-Monsalve MC,Andrade-Cetto A,Palomino-Garibay MA,et al.Hypoglycemic effect of Cecropia obtusifolia Bertol aqueous extracts on type 2 diabetic patients[J].Journal of Ethnopharmacology,2007,111(3):636-640.

[4]Kim SJ,Zaidul IS,Suzuki T,et al.Comparison of phenolic compositions between common and tartary buckwheat(Fagopyrum)sprouts[J].Food Chemistry,2008,110(4):814-820.

[5]Mali VR,Mohan V,Bodhankar SL.Antihypertensive and cardioprotective effects of the Lagenaria siceraria fruit in NGnitro-L-arginine methyl ester(L-NAME)induced hypertensive rats[J].Pharmaceutical Biology,2012,50(11):1428-1435.

[6]Ambika S,Sundrarajan M.Antibacterial behaviour of Vitex negundo extract assisted Zn O nanoparticles against pathogenic bacteria[J].Journal of Photochemistry and Photobiology B:Biology,2015,146:52-57.

[7]Gong J,Xia D,Huang J,et al.Functional components of bamboo shavings and bamboo leaf extracts and their antioxidant activities in vitro[J].Journal of Medicinal Food,2015,18(4):453-459.

[8]Lin X,Chen Y,Lv S,et al.Gypsophila elegans isoorientin attenuates CCl-induced hepatic fibrosis in rats via modulation of NF-kappaB and TGF-beta1/Smad signaling pathways[J].International Immunopharmacology,2015,28(1):305-312.

[9]Kupeli E,Aslan M,Gurbuz I,et al.Evaluation of in vivo biological activity profile of isoorientin[J].Zeitschrift für Naturforschung C,2004,59(11-12):787-790.

[10]Lim JH,Park HS,Choi JK,et al.Isoorientin induces Nrf2pathway-driven antioxidant response through phosphatidylinositol 3-kinase signaling[J].Archives of Pharmacal Research,2007,30(12):1590-1598.

[11]Choi JS,Islam MN,Ali MY,et al.The effects of C-glycosylation of luteolin on its antioxidant,anti-Alzheimer’s disease,anti-diabetic,and anti-inflammatory activities[J].Archives of Pharmacal Research,2014,37(10):1354-1363.

[12]Yuan L,Ren X,Wu Y,et al.Isoorientin protects BRL-3A rat liver cell against hydrogen peroxide-induced apoptosis by inhibiting mitochondrial dysfunction,inactivating MAPKs,activating AKT and scavenging ROS and NO[J].Biomedicine&Aging Pathology,2013,3(3):153-159.

[13]Alonso-Castro AJ,Zapata-Bustos R,Gomez-Espinoza G,et al.Isoorientin reverts TNF-alpha-induced insulin resistance in adipocytes activating the insulin signaling pathway[J].Endocrinology,2012,153(11):5222-5230.

[14]Flores G,Dastmalchi K,Dabo AJ,et al.Antioxidants of therapeutic relevance in COPD from the neotropical blueberry Anthopterus wardii[J].Food Chemistry,2012,131(1):119-125.

[15]Yuan L,Wu Y,Ren X,et al.Isoorientin attenuates lipopolysaccharide-induced pro-inflammatory responses through down-regulation of ROS-related MAPK/NF-kappaB signaling pathway in BV-2 microglia[J].Molecular and Cellular Biochemistry,2014,386(1-2):153-165.

[16]Lee W,Ku SK,Bae JS.Vascular barrier protective effects of orientin and isoorientin in LPS-induced inflammation in vitro and in vivo[J].Vascular Pharmacology,2014,62(1):3-14.

[17]陈永欣,黄权芳,林兴,等.满天星异荭草苷对大鼠酒精性肝纤维化保护作用的实验研究[J].中国中药杂志,2013,38(21):3726-3730.Chen Y,Huang Q,lin X,et al.Protective effect of isoorientin on alcohol-induced hepatic fibrosis in rats[J].China Journal of Chinese Materia Medica,2013,38(21):3726-3730.

[18]Yuan L,Wang J,Xiao H,et al.Isoorientin induces apoptosis through mitochondrial dysfunction and inhibition of PI3K/Akt signaling pathway in Hep G2 cancer cells[J].Toxicology and Applied Pharmacology,2012,265(1):83-92.

[19]Yuan L,Wang J,Xiao H,et al.MAPK signaling pathways regulate mitochondrial-mediated apoptosis induced by isoorientin in human hepatoblastoma cancer cells[J].Food and Chemical Toxicology,2013,53:62-68.

[20]Yuan L,Wang Y,Wang J,et al.Additive effect of zinc oxide nanoparticles and isoorientin on apoptosis in human hepatoma cell line[J].Toxicology Letters,2014,225(2):294-304.

[21]Yuan L,Wei S,Wang J,et al.Isoorientin induces apoptosis and autophagy simultaneously by reactive oxygen species(ROS)-related p53,PI3K/Akt,JNK,and p38 signaling pathways in Hep G2 cancer cells[J].Journal of Agricultural and Food Chemistry,2014,62(23):5390-5400.

[22]朱秀珍,申文伟,龚翠莹,等.异荭草苷体内外抗呼吸道合胞病毒活性研究[J].中山大学学报(医学科学版),2015,36(3):352-359.Zhu X,Shen W,Gong C,et al.Antiviral activity of isoorientin against respiratory syncytial virus in vitro and in vivo[J].Journal of Sun Yat-sen University(Medical Sciences),2015,36(3):352-359.

[23]Wang K.Molecular mechanisms of hepatic apoptosis[J].Cell Death&Disease,2014,5:e996.

[24]Robbins GR,Wen H,Ting JP.Inflammasomes and metabolic disorders:old genes in modern diseases[J].Molecular Cell,2014,54(2):297-308.

[25]Lamkanfi M,Dixit VM.Mechanisms and functions of inflammasomes[J].Cell,2014,157(5):1013-1022.

[26]Caramori G,Kirkham P,Barczyk A,et al.Molecular pathogenesis of cigarette smoking-induced stable COPD[J].Annals of the New York Academy of Sciences,2015,1340:55-64.

[27]Hoogland IC,Houbolt C,van Westerloo DJ,et al.Systemic inflammation and microglial activation:systematic review of animal experiments[J].Journal of Neuroinflammation,2015,12:114.

[28]Plociennikowska A,Hromada-Judycka A,Borzecka K,et al.Co-operation of TLR4 and raft proteins in LPS-induced pro-inflammatory signaling[J].Cellular and Molecular Life Sciences,2015,72(3):557-581.

[29]Chen RJ,Wu HH,Wang YJ.Strategies to prevent and reverse liver fibrosis in humans and laboratory animals[J].Archives of Toxicology,2015,89(10):1727-1750.

[30]Pelgrift RY,Friedman AJ.Nanotechnology as a therapeutic tool to combat microbial resistance[J].Advanced Drug Delivery Reviews,2013,65(13-14):1803-1815.

[31]Yakimova R,Selegard L,Khranovskyy V,et al.Zn O materials and surface tailoring for biosensing[J].Frontiers in Bioscience(Elite edition),2012,4(1):254-278.

[32]Xiong HM.Zn O nanoparticles applied to bioimaging and drug delivery[J].Advanced Materials,2013,25(37):5329-5335.

[33]Wahab R,Siddiqui MA,Saquib Q,et al.Zn O nanoparticles induced oxidative stress and apoptosis in Hep G2 and MCF-7cancer cells and their antibacterial activity[J].Colloids and Surfaces B:Biointerfaces,2014,117:267-276.

[34]王继双,何焱,张文静,等.木犀草素的药理作用研究进展[J].生命科学,2013,25(6):560-565.Wang J,He Y,Zhang W,et al.Advances in studies on pharmacological effects of luteolin[J].Chinese Bulletin of Life Sciences,2013,25(6):560-565.

[35]郭红,徐俊.荭草苷药理作用研究进展[J].中国民族民间医药,2014,(10):5-6.Guo H,Xu J.Pharmacological effects of orientin[J].Chinese Journal of Ethnomedicine and Ethnopharmacy,2014,(10):5-6.

[36]Xu T,Li D,Jiang D.Targeting cell signaling and apoptotic pathways by luteolin:cardioprotective role in rat cardiomyocytes following ischemia/reperfusion[J].Nutrients,2012,4(12):2008-2019.

基本信息:

DOI:10.16289/j.cnki.1002-0837.2016.05.014

中图分类号:R285

引用信息:

[1]罗成,李艳,龙建纲等.异荭草素的药理作用[J].航天医学与医学工程,2016,29(05):381-384.DOI:10.16289/j.cnki.1002-0837.2016.05.014.

基金信息:

中央高校基本科研业务费专项资金资助项目(08143008,08143101)

检 索 高级检索

引用

GB/T 7714-2015 格式引文
MLA格式引文
APA格式引文