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随着载人航天技术的发展，长期太空任务逐渐成为现实，长期驻留睡眠障碍问题日益突出。太空环境中的微重力、异常昼夜节律、密闭空间压力及心理应激等因素共同作用，导致人体睡眠质量显著下降，表现为入睡困难、睡眠碎片化及深度睡眠减少。本文基于中医理论系统分析了在轨人睡眠障碍的中医病因病机，并揭示了经皮穴位电刺激技术在航天医学中的独特优势，为构建非药物睡眠干预体系提供了新思路。尽管存在技术难题，经皮穴位电刺激技术等非药物疗法有望成为解决睡眠障碍的有效措施，为长期太空飞行健康睡眠提供技术支持。
Abstract：With the development of manned space technology, long-term space missions have gradually become a reality, but the problem of sleep disorders faced by astronauts has become increasingly prominent. The combined effects of microgravity, abnormal circadian rhythm, confined space pressure and psychological stress in space environment lead to the significant decline of sleep quality of astronauts, which is manifested as difficulty falling asleep, sleep fragmentation and reduction of deep sleep. Based on the theory of traditional Chinese medicine, this paper systematically analyzes the etiology and pathogenesis of astronaut sleep disorders, and reveals the unique advantages of transcutaneous electrical acupoint stimulation in space medicine, which provides a new idea for the construction of non-pharmacological sleep intervention system. Although there are technical difficulties, nonpharmacological therapy such as transcutaneous electrical acupoint stimulation is still a key breakthrough to solve sleep disorders in astronauts. It is expected to become an important part of space medicine and provide safe and efficient health protection for long-term space missions.
[1]毛莉，陈磊.探索月球基地建设的中国方案[J].科学大观园，2025(1):38-39.
[2]Adkins AM,Colby EM,Boden AF,et al.Differential impact of social isolation and space radiation on behavior and motor learning in rats[J].Life (Basel),2023,13(3):826.
[3]刘艳骄，刘征宇，陈武山.航天环境中的睡眠与睡眠障碍[J].世界睡眠医学杂志，2022,9(8):1571-1574.
[4]Barger LK,Flynn-evans EE,Kubey A,et al.Prevalence of sleep deficiency and use of hypnotic drugs in astronauts before,during,and after spaceflight:an observational study[J].The Lancet Neurology,2014,13(9):904-912.
[5]王尊升，唐晓英，刘伟峰，等.在轨睡眠及其对航天员认知的影响综述[J].航天医学与医学工程，2018,31(6):663-668.
[6]Flynn-evans EE,Barger LK,Kubey AA,et al.Circadian misalignment affects sleep and medication use before and during spaceflight[J].NPJMicrogravity,2016,2:15019.
[7]Dinges DF,Basner M,Ecker AJ,et al.Effects of zolpidem and zaleplon on cognitive performance after emergent morning awakenings at Tmax:A randomized placebo-controlled trial[J].Sleep,2019,42(3):258.
[8]Tsay WY,Chen LY,Wu SC,et al.Trends in the use and nonmedical use of sedatives-hypnotics in the population aged 12 to 64 years in Taiwan:a comparative analysis of the national surveys in 2014 and2018[J].BMC Public Health,2024,24(1):3262.
[9]黄贵伟，袁冬梅，黄旭文.中医针灸为何能够“针”服全球[J].科学之友，2025(1):48-49.
[10]王迎冬，陶雅文，于艺，等.航天医学问题针灸适应证穴位组库的构建思路与方法[J].航天医学与医学工程,2024,35(5):319-324.
[11]杨全欧，李志辉，秦远田，等.航天员出舱牵引构型设计与结构响应性能评估[J].宇航学报，2023,44(2):168-177.
[12]Hirayama J,Hattor I A,Takahashi A,et al.Physiological consequences of space flight,including abnormal bone metabolism,space radiation injury,and circadian clock dysregulation:Implications of melatonin use and regulation as a countermeasure[J].Journal of Pineal Research,2023,74(1):e12834.
[13]Cruz-sanabria F,Carmassi C,Bruno S,et al.Melatonin as a Chronobiotic with Sleep-promoting Properties[J].Current Neuropharmacology,2023,21(4):951-987.
[14]Rahman SA,Kent BA,Grant LK,et al.Effects of dynamic lighting on circadian phase,self-reported sleep and performance during a 45-day space analog mission with chronic variable sleep deficiency[J].Journal of Pineal Research,2022,73(4):e12826.
[15]李玉娟，吴爱佳，汪家苹，等.微重力效应激活VEGFR2/RAP1B/ERK通路促进h CMEC/D3细胞血管生成[J].北京理工大学学报，2025,45(7):764-770.
[16]董德朋，汪毅.助力中国航天：微重力环境运动应对理论与实践探索[J].体育科学，2022,42(9):55-71.
[17]Sun SY,Chen GH.Treatment of Circadian Rhythm Sleep-Wake Disorders[J].Current Neuropharmacology,2022,20(6):1022-1034.
[18]胡金，韦姗姗姜海洲，等.失眠的药物治疗研究进展[J].中国中药杂志，2023,48(19):5122-5130.
[19]Nicolaides NC,Vgontzas AN,Kritikou I,et al.HPA Axis and Sleep[M].South Dartmouth (MA):MDText.com,Inc.,2000.
[20]Gabinet NM,Portnov BA.Investigating the combined effect of ALANand noise on sleep by simultaneous real-time monitoring using low-cost smartphone devices[J].Environmental Research,2022,214(Pt 2):113941.
[21]Mehrotra A,Shukla SP,Shukla AK,et al.A comprehensive review of auditory and non-auditory effects of noise on human health[J].Noise Health,2024,26(121):59-69.
[22]熊志远，尚文锦，吴瑞，等.太空站某装置及支承结构的噪声测试、分析及降噪措施探讨[J].噪声与振动控制，2017,37(3):207-210.
[23]刘经建.空间站舱内环境噪声的危害与降噪措施[C].中国宇航学会深空探测技术专业委员会第六届学术年会暨863计划“深空探测与空间实验技术”重大项目学术研讨会论文集，2009:488-490.
[24]郭全红.睡眠解析[M].北京：世界图书出版公司，2018.
[25]邓晓瑞.有限空间空气稳定性对人体呼吸微环境的影响研究[D].长沙：湖南大学，2020.
[26]Finseth T,Dorneich MC,Keren N,et al.Virtual reality adaptive training for personalized stress inoculation[J].Hum Factors,2025,67(1):5-20.
[27]朱纯，吴吉萍.基于“水火相济”理论治疗糖尿病失眠[J].内蒙古中医药，2024,43(11):79-81.
[28]徐波，朱秒，孙康，等.失眠与皮肤衰老异病同“因-机-证-治-防”的理论探赜[J].中国实验方剂学杂志，2019,15(2):1-8.
[29]张文江，侯春艳，樊长征.从“虚-瘀-毒”论治慢性阻塞性肺疾病合并睡眠呼吸暂停综合征[J].中国医药导报，2018,15(22):112-114.
[30]颜紫盈，刘建和.刘建和教授基于开阖枢理论结合“六经病欲解时”治疗失眠经验浅析[J].云南中医中药杂志，2025,46(4):116-119.
[31]孟祥飞，郭义，王皓朔，等.太空环境失重生理效应中医阴阳病机分析[J].中国中医药信息杂志，2022,29(8):5-8.
[32]牛媛媛，刘磊.气机升降理论临床运用心得体会[J].中医研究，2025,38(3):30-33.
[33]张飞虎，王宇，刘阳，等.从“急性虚证”理论探析急危重症辨治[J].山东中医药大学学报，2024,48(5):546-550.
[34]江玲，薛刚，王道成，等.王道成治疗不寐经验撷菁[J].山西中医，2022,38(5):4-6.
[35]孔帅，朱临潼，魏婕，等.针灸联合归脾汤治疗心脾两虚型慢性失眠的效果及对患者睡眠质量的影响[J].大医生，2025,10(5):83-86.
[36]杨邻，王世祺，杨昆蓉.基于“心肾相交”理论探讨益肾养心安神片治疗心肾不交型失眠症[C].第二十一届国际络病学大会论文集，2025.
[37]杨彩云，谌建平，钟小微.张春馀主任医师从五脏论治失眠经验[J].中国中医药现代远程教育，2025,23(4):65-68.
[38]郑旭威.温针灸治疗阳虚体质失眠的临床疗效观察[D].广州：广州中医药大学，2021.
[39]李多，张国清，岳媛.百合地黄汤联合针刺治疗阴虚体质失眠的临床疗效观察[J].内蒙古中医药，2024,43(2):11-13.
[40]孙咪.基于转录组测序的针刺干预气郁质的机制研究[D].济南：山东中医药大学：2022.
[41]李林旺.柴胡疏肝散联合针刺治疗气郁体质失眠症的疗效观察[D].呼和浩特：内蒙古医科大学，2023.
[42]朱征，高昊昊，刘凇含，等.经皮穴位电刺激的研究现状和趋势--基于Cite Space和VOSviewer的可视化分析[J].天津中医药大学学报，2025,44(2):160-167.
[43]刘晓钰.经皮穴位电刺激对急进高原后睡眠质量的影响研究[D].西安：中国人民解放军空军军医大学，2024.
[44]董莉，戚晓霞，杨莹，等.经皮穴位电刺激对轮班制失眠护士睡眠质量及昼夜节律的影响[J].中国疗养医学，2022,31(2):185-187.
[45]Zhou WL,Li J;Shen XN,et al.Transcutaneous electrical acupoint stimulation (TEAS):applications and challenges[J].World Journal of Acupuncture-Moxibustion,2025,35(1):10-16.
[46]黄蓉.“五脏俞原配穴”针刺法治疗苯二氮类药物依赖性失眠的临床研究[D].成都：成都中医药大学，2024.
[47]付慧中，方月龙，蔡树河，等.浅针联合艾司唑仑治疗肝郁化火型失眠患者的随机对照试验[J].针刺研究，2022,47(12):1107-1112.
[48]张来宝，邱泉泉，周莉.经皮穴位电刺激对睡眠障碍老年患者下肢手术后疲劳及谵妄的影响[J].中国医药指南，2025,23(9):139-141.
[49]李子威.基于多生理信号反馈的耳迷走神经电刺激技术研究[D].西安：西安电子科技大学，2023.
[50]赵惠芳，叶彬彬，熊坚，等.一种便携式内关穴定位治疗仪的研发[J].中国医疗器械信息，2025,31(5):44-46.
[51]龚明.国产穿戴式经皮穴位电刺激手环预防航海晕船反应的应用研究[D].上海：中国人民解放军海军军医大学，2024.
[52]Zhao B,Bi Y,Chen Y,et al.Altered functional connectivity of the thalamus in patients with insomnia disorder after transcutaneous auricular vagus nerve stimulation therapy[J].Frontiers in Neurology,2023,14:1164869.
[53]Srinivasan V,Abathsagayam K,Suganthirababu P,et al.Effect of vagus nerve stimulation (ta VNS) on anxiety and sleep disturbances among elderly health care workers in the post COVID-19 pandemic[J].Work,2024,78(4):1149-1156.
[54]张帅.经皮耳穴迷走神经电刺激治疗失眠障碍的疗效及脑影像特征研究[D].北京：中国中医科学院，2023.
[55]Badran BW,Dowdle LT,Mithoefer OJ,et al.Neurophysiologic effects of transcutaneous auricular vagus nerve stimulation (ta VNS) via electrical stimulation of the tragus:a concurrent ta VNS/f MRI study and review[J].Focus (Am Psychiatr Publ),2022,20(1):80-89.
[56]Badran BW,Mithoefer OJ,Summer CE,et al.Short trains of transcutaneous auricular vagus nerve stimulation (ta VNS) have parameter-specific effects on heart rate[J].Brain Stimul,2018,11(4):699-708.
[57]Badran BW,Yu AB,Adair D,et al.Laboratory administration of transcutaneous auricular vagus nerve stimulation (ta VNS):technique,targeting,and considerations[J].Jove-Journal of Visualized Experiments,2019 (143):10.
[58]丁艳，陈元霄，赵梅.经皮穴位电刺激联合耳穴贴压治疗心肾不交型失眠的疗效观察[J].现代实用医学，2018,30(5):651-653.
[59]徐贤亮，汪文琴，善亮，等.经皮穴位电刺激联合耳穴压豆对老年患者髋关节术后失眠、负性情绪及5-HT、DA、β-EP的影响[J].中国医学创新，2024,21(31):28-32.
基本信息:
DOI：10.16289/j.cnki.1002-0837.2025.04004
中图分类号:R856.2
引用信息:
[1]荣培晶,赵亚楠,赵丹,等.针灸调节宇航员睡眠障碍的研究进展：中医病机解析与特色技术展望[J].航天医学与医学工程,2025,36(04):300-304.DOI:10.16289/j.cnki.1002-0837.2025.04004.
基金信息:
载人航天工程航天医学实验领域项目资助(HYZHXMX02005); 国家中医药多学科交叉创新团队项目(ZYYCXTD-D-202409); 北京市自然科学基金青年项目(7244491)