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目的研究泽兰有效部分L .F0 4对红细胞流变学的影响 ,以探讨其活血化瘀作用机理。方法用高分子右旋糖酐静脉推注造成大鼠血瘀证动物模型 ,观察泽兰L .F0 4对红细胞变形性、聚集性和膜流动性的影响。结果高分子右旋糖酐造成了大鼠红细胞变形性降低 (P <0 .0 5 ) ,聚集性增高 (P <0 .0 1 ) ,膜流动性降低 (P <0 .0 5 )。与模型组相比 ,L .F0 4大 ( 0 .61 2 g/kg)、小 ( 0 .30 6g/kg)剂量明显改善了红细胞变形性(P <0 .0 5 ) ,抑制了红细胞聚集 (P <0 .0 5 ) ;对红细胞膜流动性有增加的趋势 ,但未呈现出量效关系。结论L .F0 4可显著改善血瘀动物异常的红细胞流变学指标。
Abstract：Obiective To study the effects of active fractions from Lycopus lucidus (L.F04) on erythrocyterheology so as to investigate its mechanism of promoting blood circulation and removing blood stasis. Method The effects of L.F04 on erythrocytes deformability, aggregation, liquidity of membrane were examined in the present study and the blood stasis animal model of rats made by injecting high molecular weight dextran (HMWD) was used. Result HMWD injection decreased red blood cells deformability(P<0.05) and liquidity of membrane(P<0.01) and increased erythrocytes aggregation(P<005). Compared with the model, both L.F04 0.612 g/kg and 0.306 g/kg improved red blood cells deformability(P<0.05), inhibited erythrocytes aggregation(P<0.05), and showed the trend of improving liquidity of membrane. But there was no concentration dependence. Conclusion L.F04 can significantly improve the deviant erythrocyterheology characteristics.
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基本信息:
DOI：10.16289/j.cnki.1002-0837.2002.05.005
中图分类号:R285.5
引用信息:
[1]石宏志,高南南,李勇枝,余竞光,范全春,白桂娥.泽兰有效部分L.F04对红细胞流变学的影响[J].航天医学与医学工程,2002(05):331-334.DOI:10.16289/j.cnki.1002-0837.2002.05.005.
基金信息:
国家自然基金 (3 9770 899)