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高原低压缺氧环境易引发认知功能障碍，不仅对高原生产生活造成不良影响，更阻碍了高原的旅游开发和经济发展。针灸治疗脑病历史悠久，近年来，经皮耳迷走神经刺激（taVNS）疗法作为新型针灸方式已用于多种脑认知疾病的治疗研究，并因其便携、无创、安全的特点，具有较大的推广潜力。本文将高原认知障碍中医病因病机和高原认知障碍西医发病机制的基础研究有机结合，深入探讨了taVNS治疗急慢性高原认知障碍的效应机制：taVNS可能通过直接调节胆碱能系统，促进大脑微血管生成，增强脑神经保护并调节神经递质，进而激活蓝斑及前额叶等认知相关脑区；同时，taVNS可能通过改善睡眠质量，减轻急性高原病症状，间接发挥作用。本文旨在为高原认知障碍的“脑病耳治”提供理论支持，为高原等特殊环境脑病的治疗和研究提供了新方向和新思路。
Abstract：The hypoxic environment of high-altitude regions can lead to impaired cognitive function in humans, not only adversely affecting high-altitude production and daily life, but also hindering the development of high-altitude tourism and economic growth. Acupuncture therapy for brain disease has a long history. At present, transcutaneous auricular vagus nerve stimulation(taVNS) has been applied in the treatment and research of various cognitive impairments as a novel form of acupuncture. Due to its portability, non-invasiveness, and safety,, this therapy holds significant potential for widespread clinical application. This article integrates the traditional Chinese medical(TCM) etiology and pathogenesis of high-altitude cognitive impairment with Western medical mechanisms, systematically exploring the therapeutic mechanisms of taVNS in treating acute and chronic high-altitude cognitive dysfunction: taVNS may directly modulate the cholinergic system, promote cerebral microvascular angiogenesis, enhance neuroprotection, and regulate neurotransmitters, thereby activating cognition-related brain regions such as the locus coeruleus and prefrontal cortex. Additionally, taVNS may exert indirect effects by improving sleep quality and alleviating acute altitude sickness. This study aims to provide theoretical support for the TCM concept of “treating brain disorders via auricular stimulation” and to open new directions for the treatment and research of brain disorders in special environments such as high altitudes.
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基本信息:
DOI：10.16289/j.cnki.1002-0837.2026.02016
中图分类号:R749.1;R594.3
引用信息:
[1]田煜坤,辛陈,王馨,等.经皮耳迷走神经刺激治疗高原认知障碍的应用前景[J].航天医学与医学工程,2026,37(02):218-224.DOI:10.16289/j.cnki.1002-0837.2026.02016.
基金信息:
中央级公益性科研院所基本科研业务费专项资金资助（ZB2025008）; 国家重点研发计划（2019YFC1712205）; 北京市科协科研基金/中国中医科学院针灸所立项课题（2022031-213116,211069）
2026-04-25
2026-04-25