航天医学与医学工程

参考文献

[1]KIM J, TIERNEY BT, OVERBEY EG, et al. Single-cell multi-ome and immune profiles of the Inspiration4 crew reveal conserved, celltype, and sex-specific responses to spaceflight[J]. Nat Commun,2024, 15(1):4954.

[2]HELLWEG CHRISTINE E, BERGER T, MATTHI?D, et al. Radiation in space:relevance and risk for human missions[M]. Springer,2020.

[3]ZHANG S, WIMMER-SCHWEINGRUBER RF, YU J, et al. First measurements of the radiation dose on the lunar surface[J]. Sci Adv,2020, 6(39):1334.

[4]KERNAGIS DN, BALCER-KUBICZEK E, BAZYAR S, et al. Medical countermeasures for the hematopoietic-subsyndrome of acute radiation syndrome in space[J]. Life Sci Space Res(Amst), 2022, 35:36-43.

[5]MONTESINOS CA, KHALID R, CRISTEA O, et al. Space radiation protection countermeasures in microgravity and planetary exploration[J]. Life(Basel, Switzerland), 2021, 11(8):829.

[6]ADMINISTRATION NATIONAL AERONAUTICS AND SPACE.NASA-STD-3001 NASA space flight human-system standard volume1,revision B:crew ealth[S]. Washington DC:2022.

[7]HU S, BARZILLA JE, SEMONES E. Acute radiation risk assessment and mitigation strategies in near future exploration spaceflights[J].Life Sci Space Res(Amst), 2020, 24:25-33.

[8]DOBNEY W, MOLS L, MISTRY D, et al. Evaluation of deep space exploration risks and mitigations against radiation and microgravity[J]. Front Nucl Med, 2023, 3:1225034.

[9]DURANTE M, CUCINOTTA FA. Heavy ion carcinogenesis and human space exploration[J]. Nat Rev Cancer, 2008, 8(6):465-472.

[10]STRIGARI L, STROLIN S, MORGANTI AG, et al. Dose-effects models for space radiobiology:an overview on dose-effect relationships[J]. Front Public Health, 2021, 9:733337.

[11]AINSBURY EA, MOQUET J, SUN M, et al. The future of biological dosimetry in mass casualty radiation emergency response, personalized radiation risk estimation and space radiation protection[J]. Int J Radiat Biol, 2022, 98(3):421-427.

[12]PERNOT E, HALL J, BAATOUT S, et al. Ionizing radiation biomarkers for potential use in epidemiological studies[J]. Mutat Res,2012, 751(2):258-286.

[13]MU H, SUN J, LI L, et al. Ionizing radiation exposure:hazards,prevention, and biomarker screening[J]. Environ Sci Pollut Res Int,2018, 25(16):15294-15306.

[14]FEIVESON A, GEORGE K, SHAVERS M, et al. Predicting chromosome damage in astronauts participating in international space station missions[J]. Sci Rep, 2021, 11(1):5293.

[15]KRUKOWSKI K, JONES T, CAMPBELL-BEACHLER M, et al.Peripheral T cells as a biomarker for oxygen-ion-radiation-induced social Impairments[J]. Radiat Res, 2018, 190(2):186-193.

[16]KRUKOWSKI K, GRUE K, BECKER M, et al. The impact of deep space radiation on cognitive performance:from biological sex to biomarkers to countermeasures[J]. Sci Adv, 2021, 7(42):eabg6702.

[17]CORNFORTH MN, BEDFORD JS, BAILEY SM. Destabilizing effects of ionizing radiation on chromosomes:sizing up the Damage[J].Cytogenet Genome Res, 2021, 161(6/7):328-351.

[18]YOUK J, KWON HW, LIM J, et al. Quantitative and qualitative mutational impact of ionizing radiation on normal cells[J]. Cell Genom,2024, 4(2):100499.

[19]SHAKYAWAR SK, MISHRA NK, VELLICHIRAMMAL NN, et al.A Review of radiation-induced alterations of multi-omic profiles, radiation injury biomarkers, and countermeasures[J]. Radiat Res, 2023,199(1):89-111.

[20]GIACINTO O, LUSINI M, SAMMARTINI E, et al. Cardiovascular effects of cosmic radiation and microgravity[J]. J Clin Med, 2024,13(2):520.

[21]BROJAKOWSKA A, KOUR A, THEL MC, et al. Retrospective analysis of somatic mutations and clonal hematopoiesis in astronauts[J].Commun Biol, 2022, 5(1):828.

[22]TURTOI A, SCHNEEWEISS FH. Effect of(211)At alpha-particle irradiation on expression of selected radiation responsive genes in human lymphocytes[J]. Int J Radiat Biol, 2009, 85(5):403-412.

[23]STRICKLIN DL, VANHORNE-SEALY J, RIOS CI, et al. Neutron radiobiology and dosimetry[J]. Radiat Res, 2021, 195(5):480-496.

[24]OYEFESO F. A, GOLDBERG G, OPOKU NYPS, et al. Effects of acute low-moderate dose ionizing radiation to human brain organoids[J]. PLoS One, 2023, 18(5):e0282958.

[25]ANDERSSON B, LANGEN B, LIU P, et al. Development of a machine learning framework for radiation biomarker discovery and absorbed dose prediction[J]. Front Oncol, 2023, 13:1156009.

[26]REINDL J, KUNDRAT P, GIRST S, et al. Dosimetry of heavy ion exposure to human cells using nanoscopic imaging of double strand break repair protein clusters[J]. Sci Rep, 2022, 12(1):1305.

[27]HUANG J, WANG Q, HU Y, et al. Proteomic profiling for serum biomarkers in mice exposed to ionizing radiation[J]. Dose Response,2019, 17(4):1559325819894794.

[28]GARRETT-BAKELMAN FE, DARSHI M, GREEN SJ, et al. The NASA twins study:a multidimensional analysis of a year-long human spaceflight[J]. Science, 2019, 364(6436):eaau8650.

[29]MCDONALD JT, STAINFORTH R, MILLER J, et al. NASA genelab platform utilized for biological response to space radiation in animal models[J]. Cancers(Basel), 2020, 12(2):381.

[30]GAINES D, NESTOROVA GG. Extracellular vesicles-derived microRNAs expression as biomarkers for neurological radiation injury:Risk assessment for space exploration[J]. Life Sci Space Res(Amst),2022, 32:54-62.

[31]MINNIER J, EMMETT MR, PEREZ R, et al. Associations between lipids in selected brain regions, plasma miRNA, and behavioral and cognitive measures following(28)Si ion irradiation[J]. Sci Rep,2021, 11(1):14899.

[32]MA?ACHOWSKA B, TOMASIK B, STAWISKI K, et al. Circulating microRNAs as biomarkers of radiation exposure:a systematic review and meta-analysis[J]. Int J Radiat Oncol Biol Phys, 2020, 106(2):390-402.

[33]MCDONALD JT, KIM J, FARMERIE L, et al. Space radiation damage rescued by inhibition of key spaceflight associated miRNAs[J].Nat Commun, 2024, 15(1):4825.

[34]WEI W, BAI H, CHEN Y, et al. Circulating tRNA-derived small rnas as novel radiation biomarkers of heavy ion, proton and x-ray exposure[J]. Int J Mol Sci, 2021, 22(24):13476.

[35]BISSERIER M, SAFFRAN N, BROJAKOWSKA A, et al. Emerging role of exosomal long non-coding rnas in spaceflight-associated risks in astronauts[J]. Front Genet, 2021, 12:812188.

[36]KOTURBASH I, MIOUSSE IR, SRIDHARAN V, et al. Radiation-induced changes in DNA methylation of repetitive elements in the mouse heart[J]. Mutat Res, 2016, 787:43-53.

[37]CHEN H, ZHAO X, YANG W, et al. RNA N6-methyladenosine modification-based biomarkers for absorbed ionizing radiation dose estimation[J]. Nat Commun, 2023, 14(1):6912.

[38]UPADHYAY M, RAJAGOPAL M, GILL K, et al. Identification of plasma lipidome changes associated with low dose space-type radiation exposure in a murine model[J]. Metabolites, 2020, 10(6):252.

[39]MIOUSSE IR, SKINNER CM, SRIDHARAN V, et al. Changes in one-carbon metabolism and DNA methylation in the hearts of mice exposed to space environment-relevant doses of oxygen ions(16O)[J].Life Sci Space Res(Amst), 2019, 22:8-15.

[40]RESTIER-VERLET J, EL-NACHEF L, FERLAZZO ML, et al. Radiation on earth or in space:what does it change?[J]. Int J Mol Sci,2021, 22(7):3739.

[41]NARDI L, DAVIS NM, SANSOLINI S, et al. APHRODITE:a compact lab-on-chip biosensor for the real-time analysis of salivary biomarkers in space missions[J]. Biosensors(Basel), 2024, 14(2):72.

[42]DING LH, PARK S, XIE Y, et al. Elucidation of changes in molecular signalling leading to increased cellular transformation in oncogenically progressed human bronchial epithelial cells exposed to radiations of increasing LET[J]. Mutagenesis, 2015, 30(5):685-694.

[43]PARISET E, BERTUCCI A, PETAY M, et al. DNA Damage baseline predicts resilience to space radiation and radiotherapy[J]. Cell Rep,2020, 33(10):108434.

[44]TORRES-ROCA JF, ESCHRICH S, ZHAO H, et al. Prediction of radiation sensitivity using a gene expression classifier[J]. Cancer Res,2005, 65(16):7169-7176.

[45]OSTHEIM P, MAJEWSKI M, GLUZMAN-POLTORAK Z, et al.Predicting the radiation sensitivity of male and female rhesus macaques using gene expression[J]. Radiat Res, 2021, 195(1):25-37.

[46]LEWIS JE, KEMP ML. Integration of machine learning and genome-scale metabolic modeling identifies multi-omics biomarkers for radiation resistance[J]. Nat Commun, 2021, 12(1):2700.

[47]GONG S, YANG L, XU M, et al. A combined gene signature model for predicting radiotherapy response and relapse-free survival in laryngeal squamous cell carcinoma[J]. Cancer Cell Int, 2025, 25(1):102.

[48]PARISET E, PENNINCKX S, KERBAUL CD, et al. 53BP1 repair kinetics for prediction of in vivo radiation susceptibility in 15 mouse strains[J]. Radiat Res, 2020, 194(5):485-499.

[49]DEBBI K, TO NH, THIOLAT A, et al. Individual radiosensitivity testing in 2025:current advances and future directions for personalized radiotherapy[J]. Crit Rev Oncol Hematol, 2025, 216:104948.

[50]GOMOLKA M, BLYTH B, BOURGUIGNON M, et al. Potential screening assays for individual radiation sensitivity and susceptibility and their current validation state[J]. Int J Radiat Biol, 2020, 96(3):280-296.

[51]MASON CE, GREEN J, ADAMOPOULOS KI, et al. A second space age spanning omics, platforms and medicine across orbits[J]. Nature,2024, 632(8027):995-1008.